A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.

@article{Gunn1998ACE,
  title={A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.},
  author={Michael D Gunn and Kirsten Tangemann and Carolyn Tam and Jason G Cyster and S D Rosen and Lewis T. Williams},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 1},
  pages={
          258-63
        }
}
Preferential homing of naive lymphocytes to secondary lymphoid organs is thought to involve the action of chemokines, yet no chemokine has been shown to have either the expression pattern or the activities required to mediate this process. Here we show that a chemokine represented in the EST database, secondary lymphoid-tissue chemokine (SLC), is expressed in the high endothelial venules of lymph nodes and Peyer's patches, in the T cell areas of spleen, lymph nodes, and Peyer's patches, and in… CONTINUE READING
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