A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.

@article{Alejo2006ACD,
  title={A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.},
  author={Al{\'i} Alejo and Maria Bego{\~n}a Ruiz-Arg{\"u}ello and Yin Wan Ho and Vincent P. Smith and M. Saraiva and Antonio Alcam{\'i}},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 15},
  pages={5995-6000}
}
Variola virus (VaV) is the causative agent of smallpox, one of the most devastating diseases encountered by man, that was eradicated in 1980. The deliberate release of VaV would have catastrophic consequences on global public health. However, the mechanisms that contribute to smallpox pathogenesis are poorly understood at the molecular level. The ability of viruses to evade the host defense mechanisms is an important determinant of viral pathogenesis. Here we show that the tumor necrosis factor… CONTINUE READING

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