A chemokine/chemokine receptor signature potentially predicts clinical outcome in colorectal cancer patients.

  title={A chemokine/chemokine receptor signature potentially predicts clinical outcome in colorectal cancer patients.},
  author={Andrew Mitchell and Sarrah L. Hasanali and Daley S. Morera and Rohitha Baskar and Xin Wang and Rahil Khan and Asif M Talukder and Charles S. Li and Meenakkshy Manoharan and Andre R. Jordan and Jiaojiao Wang and Roni J. Bollag and Nagendra Singh and Daniel Albo and Santu Ghosh and Vinata B. Lokeshwar},
  journal={Cancer biomarkers : section A of Disease markers},
BACKGROUND Differential expression of chemokines/chemokine receptors in colorectal cancer (CRC) may enable molecular characterization of patients' tumors for predicting clinical outcome. OBJECTIVE To evaluate the prognostic ability of these molecules in a CRC cohort and the CRC TCGA-dataset. METHODS Chemokine (CXCL-12α, CXCL-12β, IL-17A, CXCL-8, GM-CSF) and chemokine receptor (CXCR-4, CXCR-7) transcripts were analyzed by RT-qPCR in 76 CRC specimens (normal: 27, tumor: 49; clinical cohort… Expand
Comprehensive analysis of the prognosis and immune infiltration for CXC chemokines in colorectal cancer
  • Xi Yang, Yuanfeng Wei, +7 authors Qing Guo
  • Medicine
  • Aging
  • 2021
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