A chemically functionalized magnetic nanoplatform for rapid and specific biomolecular recognition and separation.

@article{Lin2013ACF,
  title={A chemically functionalized magnetic nanoplatform for rapid and specific biomolecular recognition and separation.},
  author={Po-Chiao Lin and Ching-Ching Yu and Huan-Ting Wu and Ying-wei Lu and Chia-Li Han and An-Kai Su and Yu-Ju Chen and Chun-Cheng Lin},
  journal={Biomacromolecules},
  year={2013},
  volume={14 1},
  pages={160-8}
}
We have developed a target-molecule-functionalized magnetic nanoparticle (MNP)-based method to facilitate the study of biomolecular recognition and separation. The superparamagnetic property of MNPs allows the corresponding biomolecules to be rapidly separated from crude biofluids with a significant improvement in recovery yield and specificity. Various MNPs functionalized with tag molecules (chitin, heparin, and amylose) were synthesized for recombinant protein purification, and several probe… CONTINUE READING