A chemical screen to identify inducers of the mitochondrial unfolded protein response in C. elegans

Abstract

We previously showed that inhibition of the mevalonate pathway in C. elegans causes inhibition of protein prenylation, developmental arrest and lethality. We also showed that constitutive activation of the mitochondrial unfolded protein response, UPR(mt), is an effective way for C. elegans to become resistant to the negative effects of mevalonate pathway… (More)
DOI: 10.1080/21624054.2015.1096490

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