A chemical screen identifies small molecules that regulate hepcidin expression.

@article{Gaun2014ACS,
  title={A chemical screen identifies small molecules that regulate hepcidin expression.},
  author={Vera Gaun and Bonnie Patchen and Josephine Volovetz and Aileen W. Zhen and Aleksandr Andreev and Michael P Pollastri and Paula G. Fraenkel},
  journal={Blood cells, molecules & diseases},
  year={2014},
  volume={53 4},
  pages={231-40}
}
Hepcidin, a peptide hormone produced in the liver, decreases intestinal iron absorption and macrophage iron release via effects on ferroportin. Bone morphogenic protein and Stat3 signaling regulate Hepcidin's transcription. Hepcidin is a potential drug target for patients with iron overload syndromes because its levels are inappropriately low in these individuals. To generate a tool for identifying small molecules that modulate Hepcidin expression, we stably transfected human hepatocytes (HepG2… CONTINUE READING