A chemical probe toolbox for dissecting the cancer epigenome

Abstract

Cancer cell hallmarks are underpinned by transcriptional programmes operating in the context of a dynamic and complicit epigenomic environment. Somatic alterations of chromatin modifiers are among the most prevalent cancer perturbations. There is a pressing need for targeted chemical probes to dissect these complex, interconnected gene regulatory circuits… (More)
DOI: 10.1038/nrc.2017.26

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