A chemical platform for improved induction of human iPSCs

@article{Lin2009ACP,
  title={A chemical platform for improved induction of human iPSCs},
  author={Tongxiang Lin and Rajesh Ambasudhan and Xu Yuan and Wenlin Wendy Li and Simon A Hilcove and Ramzey Abujarour and Xiangyi Lin and Heung Sik Hahm and Ergeng Hao and Alberto Hayek and S. H. Ding},
  journal={Nature Methods},
  year={2009},
  volume={6},
  pages={805-808}
}
The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells. 

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