A chemical mechanism for tissue staining by osmium tetroxide-ferrocyanide mixtures.

@article{White1979ACM,
  title={A chemical mechanism for tissue staining by osmium tetroxide-ferrocyanide mixtures.},
  author={Dr L. O. White and Joseph E. Mazurkiewicz and Russell J. Barrnett},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1979},
  volume={27 7},
  pages={
          1084-91
        }
}
The presence of Fe(CN)6(-4) provides sequential, one-electron reduction pathways for OSO4. An equilibrium is established containing OSO4, Fe(CN)6(-4), Fe(CN)6(-3), OSO2(OH)4(-4), and labile cyano-bridged OS-Fe species containing Os in nominal oxidation states of VIII, VII, and VI. These osmium complexes are chelated by appropriately placed donor atoms in the macromolecular tissue matrix, and chelation facilitates the reduction of osmium in situ to lower oxidation states (predominantly IV) that… CONTINUE READING

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