A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint

@article{Mondragn2008ACI,
  title={A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint},
  author={Laura Mondrag{\'o}n and Lorenzo Galluzzi and Shahul Mouhamad and Mar Orz{\'a}ez and Jos{\'e}-Miguel Vicencio and Ilio Vitale and A. Figueira Moure and Angel Messeguer and Enr{\'i}que P{\'e}rez-Pay{\'a} and Guido Kroemer},
  journal={Apoptosis},
  year={2008},
  volume={14},
  pages={182-190}
}
QM31 represents a new class of cytoprotective agents that inhibit the formation of the apoptosome, the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. Here, we analyzed the cellular effects of QM31, as compared to the prototypic caspase inhibitor Z-VAD-fmk. QM31 was as efficient as Z-VAD-fmk in suppressing caspase-3 activation, and conferred a similar cytoprotective effect. In contrast to Z-VAD-fmk, QM31 inhibited the release of cytochrome c from mitochondria… CONTINUE READING

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