A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression.

@article{Zimmermann2011ACS,
  title={A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression.},
  author={Christine Zimmermann and Pierre Chymkowitch and Vegard Eldholm and Christopher D. Putnam and Jessica Margareta Lindvall and Manja Omerzu and Magnar Bj\or{\aa}s and Richard D Kolodner and Jorrit M. Enserink},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 46},
  pages={18748-53}
}
Cyclin-dependent kinases (CDKs) control the eukaryotic cell cycle, and a single CDK, Cdc28 (also known as Cdk1), is necessary and sufficient for cell cycle regulation in the budding yeast Saccharomyces cerevisiae. Cdc28 regulates cell cycle-dependent processes such as transcription, DNA replication and repair, and chromosome segregation. To gain further insight into the functions of Cdc28, we performed a high-throughput chemical-genetic array (CGA) screen aimed at unraveling the genetic network… CONTINUE READING
Highly Cited
This paper has 22 citations. REVIEW CITATIONS
13 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…