A chemical-genetic approach to study G protein regulation of beta cell function in vivo.

Abstract

Impaired functioning of pancreatic beta cells is a key hallmark of type 2 diabetes. beta cell function is modulated by the actions of different classes of heterotrimeric G proteins. The functional consequences of activating specific beta cell G protein signaling pathways in vivo are not well understood at present, primarily due to the fact that beta cell G… (More)
DOI: 10.1073/pnas.0906593106

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@article{Guettier2009ACA, title={A chemical-genetic approach to study G protein regulation of beta cell function in vivo.}, author={Jean-Marc Guettier and D Gautam and Marco Scarselli and I{\~n}igo Ruiz de Az{\'u}a and Jian Hua Li and Erica Rosemond and Xiaochao Ma and Frank J. Gonzalez and Blaine N. Armbruster and Huiyan Lu and Bryan L. Roth and Juergen Wess}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2009}, volume={106 45}, pages={19197-202} }