A chemical corrector modifies the channel function of F508del-CFTR.

@article{Chiaw2010ACC,
  title={A chemical corrector modifies the channel function of F508del-CFTR.},
  author={Patrick Kim Chiaw and Leigh Wellhauser and Ling Jun Huan and Mohabir Ramjeesingh and Christine E Bear},
  journal={Molecular pharmacology},
  year={2010},
  volume={78 3},
  pages={411-8}
}
The deletion of Phe-508 (F508del) constitutes the most prevalent cystic fibrosis-causing mutation. This mutation leads to cystic fibrosis transmembrane conductance regulator (CFTR) misfolding and retention in the endoplasmic reticulum and altered channel activity in mammalian cells. This folding defect can however be partially overcome by growing cells expressing this mutant protein at low (27 degrees C) temperature. Chemical "correctors" have been identified that are also effective in rescuing… CONTINUE READING

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