A charged prominence in the linker domain of the cysteine‐string protein Cspα mediates its regulated interaction with the calcium sensor synaptotagmin 9 during exocytosis

@article{Boal2011ACP,
  title={A charged prominence in the linker domain of the cysteine‐string protein Csp$\alpha$ mediates its regulated interaction with the calcium sensor synaptotagmin 9 during exocytosis},
  author={Fr{\'e}d{\'e}ric Boal and Michel S. Laguerre and Alexandra Milochau and Jochen Lang and Pier A. Scotti},
  journal={The FASEB Journal},
  year={2011},
  volume={25},
  pages={132 - 143}
}
The cochaperone cysteine‐string protein (Csp) is located on vesicles and participates in the control of neurotransmission and hormone exocytosis. Csp contains several domains, and our previous work demonstrated the requirement of the Csp linker domain in regulated exocytosis of insulin in rodent pancreatic β cells. We now address the molecular details to gain insight into the sequence of events during exocy‐tosis. According to pulldown experiments and in vitro binding assays, Cspα interacts… 
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