A characterization of ABL‐101 as a potential tracer for clinical fluorine‐19 MRI

  title={A characterization of ABL‐101 as a potential tracer for clinical fluorine‐19 MRI},
  author={Emeline Darçot and Roberto Colotti and David Brennan and Graeme A. Deuchar and Celestine Santosh and Ruud B. van Heeswijk},
  journal={NMR in Biomedicine},
The two main challenges that prevent the translation of fluorine‐19 (19F) MRI for inflammation monitoring or cell tracking into clinical practice are (i) the relatively low signal‐to‐noise ratio generated by the injected perfluorocarbon (PFC), which necessitates long scan times, and (ii) the need for regulatory approval and a high biocompatibility of PFCs that are also suitable for MRI. ABL‐101, an emulsion of perfluoro(t‐butylcyclohexane), is a third‐generation PFC that is already used in… 
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