A changing morphogen gradient is interpreted by continuous transduction flow.

@article{Bourillot2002ACM,
  title={A changing morphogen gradient is interpreted by continuous transduction flow.},
  author={P-Y Bourillot and Nigel Garrett and John Bertrand Gurdon},
  journal={Development},
  year={2002},
  volume={129 9},
  pages={2167-80}
}
In vertebrate development, most signalling factors behave as morphogens, eliciting divergent cell fates according to their concentration. We ask how cells interpret morphogen concentration as it changes during the establishment of a gradient. Using dissociated blastula cells of Xenopus exposed to activin for only 10 minutes, we have followed the phosphorylation of tagged Smad2, the principal activin transducer, from a cytoplasmic pool to the nucleus in real time. We show that a changing… CONTINUE READING
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of early embryos

  • S. Dyson, J. B. Gurdon
  • 1998
Highly Influential
2 Excerpts

Xenopus Smad 4 beta is the co - Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes

  • M. Howell, T. J. Mohun, C. S. Hill
  • Dev . Biol .
  • 2001

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