A changing morphogen gradient is interpreted by continuous transduction flow.

  title={A changing morphogen gradient is interpreted by continuous transduction flow.},
  author={P-Y Bourillot and Nigel Garrett and John Bertrand Gurdon},
  volume={129 9},
In vertebrate development, most signalling factors behave as morphogens, eliciting divergent cell fates according to their concentration. We ask how cells interpret morphogen concentration as it changes during the establishment of a gradient. Using dissociated blastula cells of Xenopus exposed to activin for only 10 minutes, we have followed the phosphorylation of tagged Smad2, the principal activin transducer, from a cytoplasmic pool to the nucleus in real time. We show that a changing… CONTINUE READING
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