A change of view: homologous recombination at single-molecule resolution

@article{Kaniecki2018ACO,
  title={A change of view: homologous recombination at single-molecule resolution},
  author={Kyle Stephen Kaniecki and Luisina De Tullio and Eric C Greene},
  journal={Nature Reviews Genetics},
  year={2018},
  volume={19},
  pages={191-207}
}
Genetic recombination occurs in all organisms and is vital for genome stability. Indeed, in humans, aberrant recombination can lead to diseases such as cancer. Our understanding of homologous recombination is built upon more than a century of scientific inquiry, but achieving a more complete picture using ensemble biochemical and genetic approaches is hampered by population heterogeneity and transient recombination intermediates. Recent advances in single-molecule and super-resolution… CONTINUE READING
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