A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells

@inproceedings{Overmeyer2011ACS,
  title={A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells},
  author={J. H. Overmeyer and Ashley M Young and Haymanti Bhanot and William A Maltese},
  booktitle={Molecular Cancer},
  year={2011}
}
Methuosis is a unique form of non-apoptotic cell death triggered by alterations in the trafficking of clathrin-independent endosomes, ultimately leading to extreme vacuolization and rupture of the cell. Here we describe a novel chalcone-like molecule, 3-(2-m ethyl-1H- i ndol-3-yl)-1-(4-p yridinyl)-2-p ropen-1-one (MIPP) that induces cell death with the hallmarks of methuosis. MIPP causes rapid accumulation of vacuoles derived from macropinosomes, based on time-lapse microscopy and labeling with… CONTINUE READING