A certain step of proteolytic processing of proopiomelanocortin occurs during the transition between two distinct stages of secretory granule maturation in rat anterior pituitary corticotrophs.

Abstract

To obtain antibodies specific for precursor POMC and its cleaved peptides, we prepared synthetic peptides corresponding to the cleavage site (ST-1) between ACTH and beta-lipotropic hormone moieties of POMC and to amidated joining peptide (JP; ST-3) and generated their polyclonal antibodies in rabbits. The anti-ST-1 serum immunoprecipitated only POMC in the… (More)

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@article{Tanaka1992ACS, title={A certain step of proteolytic processing of proopiomelanocortin occurs during the transition between two distinct stages of secretory granule maturation in rat anterior pituitary corticotrophs.}, author={Sachiko Tanaka and Kazumasa Kurosumi}, journal={Endocrinology}, year={1992}, volume={131 2}, pages={779-86} }