A cerebellar tremor/ataxia syndrome among fragile X premutation carriers.

  title={A cerebellar tremor/ataxia syndrome among fragile X premutation carriers.},
  author={Paul J. Hagerman and Claudia M. Greco and Randi J. Hagerman},
  journal={Cytogenetic and genome research},
  volume={100 1-4},
Fragile X syndrome is a neurodevelopmental disorder that is not known to have any progressive neurological sequelae in adulthood. However, a neurological condition involving intention tremor, ataxia, and cognitive decline has recently been identified among older male carriers of premutation alleles of the FMR1 gene. This condition is clinically distinct from fragile X syndrome and arises through a different molecular mechanism involving the same gene (FMR1). Characteristic findings on magnetic… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 12 extracted citations

Assessment of a clinical checklist in the diagnosis of fragile X syndrome in India.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia • 2009
View 1 Excerpt

Human chromosome fragility.

Biochimica et biophysica acta • 2008

The pathophysiology of fragile x syndrome.

Annual review of genomics and human genetics • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…