A century of cerebellar somatotopy: a debated representation

@article{Manni2004ACO,
  title={A century of cerebellar somatotopy: a debated representation},
  author={Ermanno Manni and Laura Petrosini},
  journal={Nature Reviews Neuroscience},
  year={2004},
  volume={5},
  pages={241-249}
}
The existence of functional localization within the cerebellum was advanced exactly one century ago by both comparative anatomical and physiological studies. Here, we will discuss how models of cerebellar localization have evolved over the last 100 years. Like the somatotopic representation in neocortical sensorimotor areas, the representation size of different body parts in the cerebellum does not reflect their peripheral extent, but rather the different demands on the sensory inputs for… 
View on Nature
mail.physiol.gu.se
218 Citations
Highly Influential Citations
13
Background Citations
99
Methods Citations
11
Results Citations
15

218 Citations

Neurofunctional Aspects of Cerebellum: The End of a Dogma

TLDR
In this review, the authors come with the latest information about the Cerebellar functions, whereas the syndrome cerebellar cognitive-affective, it correlated, putting an end to morea dogma in neuroscience.

Retinotopic maps of visual space in the human cerebellum

TLDR
These findings imply that the cerebellum is closely involved in visuospatial cognition, and that its contributions are anchored in sensory coordinates.

The human cerebellum: a review of physiologic neuroanatomy.

Anatomical and physiological foundations of cerebellar information processing

TLDR
A model of spinocerebellar interactions in which the structure–functional organizing principle is a division of the cerebellum into discrete microcomplexes is presented, which reveals salient features of cerebellar information processing.

Reorganization in cerebral and cerebellar cortices is not restricted by proximity between body-part representations

TLDR
It is demonstrated that information from the same body-parts is processed in the hand regions of both the cerebral cortex and cerebellum, demonstrating alternative drivers of reorganization, and particularly the possible role of adaptive behavior and sub-cortical plasticity.

Mapping motor representations in the human cerebellum.

TLDR
Electrics stimulated the posterior cerebellum of 20 human patients undergoing surgery for tumours located outside this structure, suggesting that electrically evoked motor responses were not mediated by a cortical route but rather by brainstem structures.

Juggling with the brain - thought and action in the human motor system.

A Third Somatomotor Representation in the Human Cerebellum

TLDR
Direct support for a third somatomotor map in the vermis of the cerebellum is provided by using intensive, repeated functional MRI scanning of individuals performing movements across multiple body parts.

The cerebellum and its contribution to complex tasks in higher primates: A comparative perspective

Functional implications of tactile projection patterns to the lateral hemispheres of the cerebellum of the albino rat: the legacy of Wally Welker

  • J. Bower
  • Biology
    Annals of the New York Academy of Sciences
  • 2011
TLDR
The major results of these micromapping experiments are summarized and the relationship between these fundamental discoveries and Wally Welker's theory‐neutral approach to experimental science is explored.
...

References

SHOWING 1-10 OF 86 REFERENCES

Sensorimotor mapping of the human cerebellum: fMRI evidence of somatotopic organization

TLDR
Functional magnetic resonance imaging was employed to determine areas of activation in the cerebellar cortex in 46 human subjects during a series of motor tasks and representations were observed that seem to confirm earlier electrophysiological findings of sagittal zones in animals.

Organizational Principles of Cerebellar Neuronal Circuitry.

  • M. GarwiczC. EkerotH. Jörntell
  • Biology, Psychology
    News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
  • 1998
TLDR
It is argued that consideration of organizational features of cerebellar circuitry represents a necessary step toward the understanding of how the cerebellum does what it does, in terms of both its internal information processing and its interaction with other motor structures.

A functional MRI study of somatotopic representation of somatosensory stimulation in the cerebellum

TLDR
In the anterior and posterior cerebellum, activated pixels for the index finger and big toe were separate from those for the toe, suggesting that somatosensory stimulation of different parts of the body may involve distinct areas of in the Cerebellum as well as the cerebral cortex.

Functional localization in the cerebellum. II. Somatotopic organization in cortex and nuclei.

TLDR
A new concept of the organization of the cerebellum into longitudinal, corticonuclear zones has been formulated on the basis of anatomical studies of Jansen and Brodal* and on their own physiological observations, which stresses the importance of localization in the efferent corticon nuclear projections.

The cerebellar corticonuclear projection from lobule Vb/c of the cat anterior lobe: a combined electrophysiological and autoradiographic study

TLDR
Investigation of the efferent pathways from Purkinje cells within particular sagittal zones of the vermal region of the cat cerebellar cortex showed that the smallest injections gave rise to injection sites which were restricted to a single zone and to terminal labelling which was very reproducible between cases.

Lateral cerebellum: functional localization within crus I and correspondence to cortical zones

TLDR
It is suggested that a potent source of CF input to the C2 and D1 zones within this region of cortex arises from visual pathways.

The cerebellar corticonuclear projection from lobule Vb/c of the cat anterior lobe: a combined electrophysiological and autoradiographic study

TLDR
It was found that the smallest injections resulted in injection sites restricted to a single cortical zone and extremely reproducible results could be obtained using such a combined electrophysiological/autoradiographic technique.

Movement-related gating of climbing fibre input to cerebellar cortical zones

Congruence of mossy fiber and climbing fiber tactile projections in the lateral hemispheres of the rat cerebellum

TLDR
The spatial relationship between the mossy fiber and climbing fiber projections to crus IIa in the lateral hemispheres of the rat cerebellum is examined and it is shown that the two pathways converge at the level of single Purkinje cells.

Luciani's work on the cerebellum a century later

...