A centrally-mediated effect of morphine to diminish hepatocellular glutathione.

Abstract

Morphine administration has been associated with a decrease in hepatic glutathione (GSH) and an increase in the hepatotoxicity of compounds dependent upon GSH for detoxification. In this study, intraperitoneal administration of 100 mg/kg morphine in mice resulted in approximately a 25% decrease in hepatic GSH. The same magnitude of GSH depletion was also… (More)

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@article{Roberts1987ACE, title={A centrally-mediated effect of morphine to diminish hepatocellular glutathione.}, author={Stephen M. Roberts and N P Skoulis and Ryan C. James}, journal={Biochemical pharmacology}, year={1987}, volume={36 18}, pages={3001-5} }