A central role of interferon regulatory factor-1 for the limitation of neointimal hyperplasia.

@article{Wessely2003ACR,
  title={A central role of interferon regulatory factor-1 for the limitation of neointimal hyperplasia.},
  author={Rainer Wessely and Ludger Hengst and Birgit Jaschke and Franziska Wegener and Thomas Richter and Raffaella Lupetti and Makarios Paschalidis and Albert Schoemig and Richard Brandl and F. Neumann},
  journal={Human molecular genetics},
  year={2003},
  volume={12 2},
  pages={
          177-87
        }
}
Neointima formation, the leading cause of restenosis after catheter angioplasty, is a paradigm for vascular proliferative responses. Neointima formation is self-limiting after a variable degree of tissue growth, causing significant renarrowing in a substantial number of patients. To investigate the mechanisms that limit neointima formation we studied the role of the transcription factor IRF-1, which is a regulator of interferons and a tumor suppressor. We demonstrate that IRF-1 is highly… CONTINUE READING

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