A central role for vimentin in regulating repair function during healing of the lens epithelium

@inproceedings{Menko2014ACR,
  title={A central role for vimentin in regulating repair function during healing of the lens epithelium},
  author={A. Sue Menko and Brigid M. Bleaken and A. A. Libowitz and Lin Zhang and Michael Stepp and J. A. Lucy Walker},
  booktitle={Molecular biology of the cell},
  year={2014}
}
Mock cataract surgery provides a unique ex vivo model for studying wound repair in a clinically relevant setting. Here wound healing involves a classical collective migration of the lens epithelium, directed at the leading edge by an innate mesenchymal subpopulation of vimentin-rich repair cells. We report that vimentin is essential to the function of repair cells as the directors of the wound-healing process. Vimentin and not actin filaments are the predominant cytoskeletal elements in the… CONTINUE READING
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