A central role for Pyk2-Src interaction in coupling diverse stimuli to increased epithelial NBC activity.

@article{Espiritu2002ACR,
  title={A central role for Pyk2-Src interaction in coupling diverse stimuli to increased epithelial NBC activity.},
  author={Doris Joy D Espiritu and Angelito A Bernardo and R Brooks Robey and Jose A. L. Arruda},
  journal={American journal of physiology. Renal physiology},
  year={2002},
  volume={283 4},
  pages={
          F663-70
        }
}
Regulation of renal Na-HCO cotransporter (NBC1) activity by cholinergic agonists, ANG II, and acute acidosis (CO(2)) requires both Src family kinase (SFK) and classic MAPK pathway activation. The nonreceptor tyrosine kinase proline-rich tyrosine kinase 2 (Pyk2) couples discrete G protein-coupled receptor and growth factor receptor signaling to SFK activation. We examined the role of Pyk2-SFK interaction in coupling these stimuli to increased NBC1 activity in opossum kidney cells. Carbachol… 
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TLDR
It is concluded that angiotensin II activates ERK and cPLA2alpha in a concentration-dependent manner via AT1, and that the balance between ERk and c PLA2alpha activities determines the ultimate response to Ang II in intact proximal tubules.
Regulation of Renal Na+/HCO3− Cotransporter Stimulation by CO2: Role of Phosphorylation, Exocytosis and Protein Synthesis
TLDR
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ANG II and calmodulin/CaMKII regulate surface expression and functional activity of NBCe1 via separate means.
We recently reported that ANG II inhibits NBCe1 current and surface expression in Xenopus laevis oocytes (Perry C, Blaine J, Le H, and Grichtchenko II. Am J Physiol Renal Physiol 290: F417-F427,…
Src and Pyk2 mediate angiotensin II effects in cultured rat astrocytes
Src-family tyrosine kinases and the Ca2+ signal.
Interaction of Membrane Skeletal Protein, Protein 4.1B and p55, and Sodium Bicarbonate Cotransporter1 in Mouse Renal S1-S2 Proximal Tubules
  • N. Terada, N. Ohno, +6 authors S. Ohno
  • Biology
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 2007
TLDR
It is proposed that the 4.1B-containing membrane skeleton may play a role in regulating the Na+ and HCO3 - reabsorption in S1-S2 proximal tubules.
Role of NH(2) and COOH termini in targeting, stability, and activity of sodium bicarbonate cotransporter 1.
TLDR
It is found that decreased DeltaC92 expression in the basolateral membrane was due to increased endocytosis and mistargeting to the apical membrane, and the COOH terminus plays a role on NBC1 stability in thebasolateral membranes.
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