A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery

@inproceedings{Rohs2018ACR,
  title={A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery},
  author={Patricia D A Rohs and Jackson Buss and Sue I Sim and Georgia R Squyres and Veerasak Srisuknimit and Mandy Smith and Hongbaek Cho and Megan Marie Sjodt and Andrew C Kruse and Ethan C Garner and Suzanne Walker and Daniel E Kahne and Thomas G Bernhardt},
  booktitle={PLoS genetics},
  year={2018}
}
Cell elongation in rod-shaped bacteria is mediated by the Rod system, a conserved morphogenic complex that spatially controls cell wall assembly by the glycan polymerase RodA and crosslinking enzyme PBP2. Using Escherichia coli as a model system, we identified a PBP2 variant that promotes Rod system function when essential accessory components of the machinery are inactivated. This PBP2 variant hyperactivates cell wall synthesis in vivo and stimulates the activity of RodA-PBP2 complexes in… CONTINUE READING
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