A central role for JNK in obesity and insulin resistance

@article{Hirosumi2002ACR,
  title={A central role for JNK in obesity and insulin resistance},
  author={Jiro Hirosumi and Gurol Tuncman and Lufen Chang and Cem Z. G{\"o}rg{\"u}n and K. Teoman Uysal and Kazuhisa Maeda and Michael Karin and G{\^o}khan S. Hotamisligil},
  journal={Nature},
  year={2002},
  volume={420},
  pages={333-336}
}
Obesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the molecular mechanisms of this association are poorly understood. The c-Jun amino-terminal kinases (JNKs) can interfere with insulin action in cultured cells and are activated by inflammatory cytokines and free fatty acids, molecules that have been implicated in the development of type 2 diabetes. Here we show that JNK activity is abnormally elevated in obesity… 
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