A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination.

@article{Lane2000ACR,
  title={A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination.},
  author={Thomas E Lane and Michael T. Liu and Benjamin PC. Chen and Val{\'e}rie C. Asensio and R M Samawi and A. Paoletti and Iain L Campbell and Steven L. Kunkel and Howard S. Fox and Michael J Buchmeier},
  journal={Journal of virology},
  year={2000},
  volume={74 3},
  pages={1415-24}
}
Infection of C57BL/6 mice with mouse hepatitis virus (MHV) results in a demyelinating encephalomyelitis characterized by mononuclear cell infiltration and white matter destruction similar to the pathology of the human demyelinating disease multiple sclerosis. The contributions of CD4(+) and CD8(+) T cells in the pathogenesis of the disease were investigated. Significantly less severe inflammation and demyelination were observed in CD4(-/-) mice than in CD8(-/-) and C57BL/6 mice (P < or = 0.002… CONTINUE READING
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