A central regulator of morphological differentiation in the multicellular bacterium Streptomyces coelicolor.

@article{Nguyen2002ACR,
  title={A central regulator of morphological differentiation in the multicellular bacterium Streptomyces coelicolor.},
  author={Kien T. Nguyen and Joanne M Willey and Liem D Nguyen and Lieu thi Nguyen and Patrick H Viollier and Charles B. Thompson},
  journal={Molecular microbiology},
  year={2002},
  volume={46 5},
  pages={1223-38}
}
In the multicellular bacterium Streptomyces coelicolor, functions of developmental (bald) genes are required for the biosynthesis of SapB, a hydrophobic peptidic morphogen that facilitates aerial hyphae formation. Here, we show that aerial hyphal growth and SapB biosynthesis could be activated independently from the normal developmental cascade by providing unprogrammed expression of functionally interactive genes within the ram cluster. ramC, ramS and ramR were essential for normal growth of… CONTINUE READING

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