A central multifunctional role of integrin-linked kinase at muscle attachment sites.

@article{Zervas2011ACM,
  title={A central multifunctional role of integrin-linked kinase at muscle attachment sites.},
  author={Christos G. Zervas and Eleni Psarra and Victoria M Williams and Esther C Solomon and Katerina M. Vakaloglou and Nicholas H. Brown},
  journal={Journal of cell science},
  year={2011},
  volume={124 Pt 8},
  pages={1316-27}
}
Integrin-linked kinase (ILK) is an essential component of a multiprotein complex that links actin to the plasma membrane. Here, we have used a genetic approach to examine the molecular interactions that are essential for the assembly of this ILK-containing complex at Drosophila muscle attachment sites (MASs). We show that, downstream of integrins, talin plays a decisive role in the recruitment of three proteins: ILK, PINCH and paxillin. The accumulation of ILK at MASs appears to follow an… CONTINUE READING

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The structural basis of integrin-linked kinase-PINCH interactions.

Proceedings of the National Academy of Sciences of the United States of America • 2008

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