A census of human transcription factors: function, expression and evolution

  title={A census of human transcription factors: function, expression and evolution},
  author={Juan M. Vaquerizas and Sarah K. Kummerfeld and Sarah A. Teichmann and Nicholas M. Luscombe},
  journal={Nature Reviews Genetics},
Transcription factors are key cellular components that control gene expression: their activities determine how cells function and respond to the environment. Currently, there is great interest in research into human transcriptional regulation. However, surprisingly little is known about these regulators themselves. For example, how many transcription factors does the human genome contain? How are they expressed in different tissues? Are they evolutionarily conserved? Here, we present an… 

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