A census of human transcription factors: function, expression and evolution

@article{Vaquerizas2009ACO,
  title={A census of human transcription factors: function, expression and evolution},
  author={Juan M. Vaquerizas and Sarah K. Kummerfeld and Sarah A. Teichmann and Nicholas M. Luscombe},
  journal={Nature Reviews Genetics},
  year={2009},
  volume={10},
  pages={252-263}
}
Transcription factors are key cellular components that control gene expression: their activities determine how cells function and respond to the environment. Currently, there is great interest in research into human transcriptional regulation. However, surprisingly little is known about these regulators themselves. For example, how many transcription factors does the human genome contain? How are they expressed in different tissues? Are they evolutionarily conserved? Here, we present an… 

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The recently discovered rapid 're-wiring' of in vivo transcription factor binding between related metazoan species is reviewed and general principles underlying the observed patterns of evolution are summarized.

Transcription factors and evolution: An integral part of gene expression (Review)

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