A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes.

@article{ElBattrawy2019ACM,
  title={A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes.},
  author={Ibrahim El-Battrawy and Sebastian Albers and Lukas Cyganek and Zhihan Zhao and Huan Lan and Xin Li and Qiang Xu and Mandy Kleinsorge and Mengying Huang and Zhenxing Liao and Rujia Zhong and Boris Rudic and Jonas M{\"u}ller and Hendrik Dinkel and Siegfried Lang and Sebastian Diecke and Wolfram H. Zimmermann and Jochen Sven Utikal and Thomas Wieland and Martin Borggrefe and Xiaobo Zhou and Ibrahim Akin},
  journal={Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology},
  year={2019}
}
AIMS Brugada syndrome (BrS) is associated with a pronounced risk to develop sudden cardiac death (SCD). Up to 21% of patients are related to mutations in SCN5A. Studies identified SCN10A as a contributor of BrS. However, the investigation of the human cellular phenotype of BrS in the presence of SCN10A mutations remains lacking. The objective of this study was to establish a cellular model of BrS in presence of SCN10A mutations using human-induced pluripotent stem cell-derived cardiomyocytes… CONTINUE READING