A cellular mechanism for cortical associations: an organizing principle for the cerebral cortex

@article{Larkum2013ACM,
  title={A cellular mechanism for cortical associations: an organizing principle for the cerebral cortex},
  author={Matthew Evan Larkum},
  journal={Trends in Neurosciences},
  year={2013},
  volume={36},
  pages={141-151}
}
  • M. Larkum
  • Published 2013
  • Psychology, Medicine
  • Trends in Neurosciences
A basic feature of intelligent systems such as the cerebral cortex is the ability to freely associate aspects of perceived experience with an internal representation of the world and make predictions about the future. Here, a hypothesis is presented that the extraordinary performance of the cortex derives from an associative mechanism built in at the cellular level to the basic cortical neuronal unit: the pyramidal cell. The mechanism is robustly triggered by coincident input to opposite poles… Expand
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References

SHOWING 1-10 OF 122 REFERENCES
Neuronal circuits of the neocortex.
TLDR
It is found that, as has long been suspected by cortical neuroanatomists, the same basic laminar and tangential organization of the excitatory neurons of the neocortex is evident wherever it has been sought. Expand
Feedforward, feedback and inhibitory connections in primate visual cortex
  • E. Callaway
  • Computer Science, Medicine
  • Neural Networks
  • 2004
TLDR
Observations of the functional interactions between cortical areas and modules and the mechanisms by which fine scale microcircuits influence interactions at more coarse levels of organization have informed current views about the functions of these circuits. Expand
Interneurons of the neocortical inhibitory system
TLDR
This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits. Expand
Conserved patterns of cortico-cortical connections define areal hierarchy in rat visual cortex
TLDR
These laminar patterns resemble those of forward and feedback connections in primate cortex, indicating that cortico-cortical connectivity patterns are highly conserved through evolution, and that, as in monkeys, these connections define a hierarchical organization of areas in rat visual cortex. Expand
Single-neuron theory of consciousness.
  • S. Sevush
  • Biology, Medicine
  • Journal of theoretical biology
  • 2006
TLDR
A contrasting model is presented in the present paper that places the mind/brain interface not at the whole brain level but at the level of single neurons, and proposes that each neuron in the nervous system is independently conscious, with conscious content corresponding to the spatial pattern of a portion of that neuron's dendritic electrical activity. Expand
The role of single neurons in information processing
TLDR
The role of neurons has evolved conceptually from that of a simple integrator of synaptic inputs until a threshold is reached and an output pulse is initiated, to a much more sophisticated processor with mixed analog-digital logic and highly adaptive synaptic elements. Expand
Evolution of consciousness.
  • J. Eccles
  • Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1992
TLDR
It is proposed that the whole world of consciousness, the mental world, is microgranular, with mental units called psychons, and that in mind-brain interaction one psychon is linked to one dendron through quantum physics. Expand
Always returning: feedback and sensory processing in visual cortex and thalamus
TLDR
A circuit formed by layer 6 feedback cells in the visual cortex is considered and how this straddles the retinothalamic and thalamocortical transfer of visual input and it is suggested that motion perception involves a dynamic interplay between MT, V1 and the thalamus. Expand
Distributed hierarchical processing in the primate cerebral cortex.
TLDR
A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on. Expand
The subcellular organization of neocortical excitatory connections
TLDR
An efficient channelrhodopsin-2 (ChR2)-assisted method to map the spatial distribution of synaptic inputs, defined by presynaptic ChR2 expression, within the dendritic arborizations of recorded neurons is developed. Expand
...
1
2
3
4
5
...