A cellular lineage analysis of the chick limb bud.

  title={A cellular lineage analysis of the chick limb bud.},
  author={Richard Pearse and Paul J. Scherz and Jacquie Kloetzli Campbell and Clifford J Tabin},
  journal={Developmental biology},
  volume={310 2},
The chick limb bud has been used as a model system for studying pattern formation and tissue development for more than 50 years. However, the lineal relationships among the different cell types and the migrational boundaries of individual cells within the limb mesenchyme have not been explored. We have used a retroviral lineage analysis system to track the fate of single limb bud mesenchymal cells at different times in early limb development. We find that progenitor cells labeled at stage 19-22… CONTINUE READING
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