A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes

@inproceedings{Suzuki2014ACG,
  title={A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes},
  author={Oscar T. Suzuki and Amber Frick and Bethany B. Parks and O. Joseph Trask and Natasha Butz and Brian M. Steffy and Emmanuel Chan and David K. Scoville and Eric Healy and Cristina S. Benton and Patricia E. McQuaid and Russell S. Thomas and Tim Wiltshire},
  booktitle={Front. Genet.},
  year={2014}
}
New approaches to toxicity testing have incorporated high-throughput screening across a broad-range of in vitro assays to identify potential key events in response to chemical or drug treatment. To date, these approaches have primarily utilized repurposed drug discovery assays. In this study, we describe an approach that combines in vitro screening with genetic approaches for the experimental identification of genes and pathways involved in chemical or drug toxicity. Primary embryonic… CONTINUE READING
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A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway

OT Citation Suzuki, A Frick, +10 authors T Wiltshire
nodes. Front. Genet. 5:272 • 2014

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction

Suzuki, Frick, +10 authors Wiltshire
Genetics. Copyright • 2014

“ Cellular genetics approaches to defining toxicity pathways

A. Frick, R. Thomas, +3 authors B. Parks
AACR Annual Meeting 2013 • 2013
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