A cellular framework for gut-looping morphogenesis in zebrafish.

  title={A cellular framework for gut-looping morphogenesis in zebrafish.},
  author={Sally Horne-Badovinac and Michael R. Rebagliati and Didier Y. R. Stainier},
  volume={302 5645},
Many vertebrate organs adopt asymmetric positions with respect to the midline, but little is known about the cellular changes and tissue movements that occur downstream of left-right gene expression to produce this asymmetry. Here, we provide evidence that the looping of the zebrafish gut results from the asymmetric migration of the neighboring lateral plate mesoderm (LPM). Mutations that disrupt the epithelial structure of the LPM perturb this asymmetric migration and inhibit gut looping… CONTINUE READING
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