A cellular calculus for signal integration by T cells

@article{Gett2000ACC,
title={A cellular calculus for signal integration by T cells},
author={Amanda V. Gett and Philip D. Hodgkin},
journal={Nature Immunology},
year={2000},
volume={1},
pages={239-244}
}

During an immune response numerous receptor-mediated signals delivered to T cells direct their proliferation, survival and differentiation. Here, we describe a quantitative model and in vitro methods for assessing the “calculus” used by T cells to process these multiple signals. The model reveals how T cells convert independently received signals into linear additive effects on division times which, in turn, amplify T cell number exponentially. These results explain why so many ligands can each… CONTINUE READING