A cellular calculus for signal integration by T cells

  title={A cellular calculus for signal integration by T cells},
  author={Amanda V. Gett and Philip D. Hodgkin},
  journal={Nature Immunology},
During an immune response numerous receptor-mediated signals delivered to T cells direct their proliferation, survival and differentiation. Here, we describe a quantitative model and in vitro methods for assessing the “calculus” used by T cells to process these multiple signals. The model reveals how T cells convert independently received signals into linear additive effects on division times which, in turn, amplify T cell number exponentially. These results explain why so many ligands can each… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS