A cellular calculus for signal integration by T cells

@article{Gett2000ACC,
  title={A cellular calculus for signal integration by T cells},
  author={Amanda V. Gett and Philip D. Hodgkin},
  journal={Nature Immunology},
  year={2000},
  volume={1},
  pages={239-244}
}
During an immune response numerous receptor-mediated signals delivered to T cells direct their proliferation, survival and differentiation. Here, we describe a quantitative model and in vitro methods for assessing the “calculus” used by T cells to process these multiple signals. The model reveals how T cells convert independently received signals into linear additive effects on division times which, in turn, amplify T cell number exponentially. These results explain why so many ligands can each… CONTINUE READING
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