A cell-surface proteoglycan mediates human adenocarcinoma HT-29 cell adhesion to human angiogenin.

@article{Soncin1994ACP,
  title={A cell-surface proteoglycan mediates human adenocarcinoma HT-29 cell adhesion to human angiogenin.},
  author={Fabrice Soncin and Robert P Shapiro and James W. Fett},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 12},
  pages={8999-9005}
}
Human angiogenin is an excellent substrate for the adhesion of HT-29 human colon adenocarcinoma cells. These cells adhere more quickly to human angiogenin than to fibronectin, laminin, collagen I, and collagen IV. Anti-angiogenin antibodies and the angiogenesis inhibitors platelet factor-4 and placental ribonuclease inhibitor prevent adhesion of HT-29 cells to angiogenin. Calcium and magnesium ions are not required for adhesion and Arg-Gly-Asp-Ser has no effect, indicating that the interaction… CONTINUE READING