A cell penetrating heme oxygenase protein protects heart graft against ischemia/reperfusion injury

Abstract

Ischemia/reperfusion (I/R) injury is an unavoidable barrier that significantly affects outcome of solid organ transplantation. Here, we establish a protein transduction system to extend graft preservation time and to prevent I/R injury in heart transplantation. We generated a recombinant heme oxygenase-1 (HO-1) protein containing a modified protein… (More)
DOI: 10.1038/gt.2008.162

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