A cell line model for the differentiation of human dendritic cells.

@article{Berges2005ACL,
  title={A cell line model for the differentiation of human dendritic cells.},
  author={Carsten Berges and Cord Naujokat and Sarah Tinapp and H. Wieczorek and Alexandra Eva Hoeh and Mahmoud Sadeghi and Gerhard Opelz and Volker Daniel},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={333 3},
  pages={
          896-907
        }
}
We have identified human monocytic (THP-1) and myelogenous CD34+ (KG-1) leukemia cell lines that can be differentiated rapidly into mature dendritic cells (DCs) when cultured in serum-free medium containing GM-CSF, TNF-alpha, and ionomycin. These hematopoietic cell line-derived DCs are highly pure and monotypic, and display the morphologic, phenotypic, molecular, and functional properties of DCs generated from human donor-derived monocytes or CD34+ hematopoietic progenitor cells. During… CONTINUE READING
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