A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair.

@article{Taylor2000ACC,
  title={A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair.},
  author={Richard M. Taylor and David J Moore and Jenna Whitehouse and Paul Johnson and Keith W. Caldecott},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 2},
  pages={735-40}
}
XRCC1 protein is essential for viability in mammals and is required for efficient DNA single-strand break repair and genetic stability following DNA base damage. We report here that XRCC1-dependent strand break repair in G(1) phase of the cell cycle is abolished by mutations created within the XRCC1 BRCT domain that interact with DNA ligase III. In contrast, XRCC1-dependent DNA strand break repair in S phase is largely unaffected by these mutations. These data describe a cell cycle-specific… CONTINUE READING

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