A cell cycle regulator potentially involved in genesis of many tumor types.

@article{Kamb1994ACC,
  title={A cell cycle regulator potentially involved in genesis of many tumor types.},
  author={Alexander Kamb and Nelleke A. Gruis and Jane Weaver-Feldhaus and Qinghua Liu and Keith Harshman and Sean V. Tavtigian and Elisabeth Stockert and Rufus S. Day and Bruce Evan Johnson and Mark H. Skolnick},
  journal={Science},
  year={1994},
  volume={264 5157},
  pages={436-40}
}
A putative tumor suppressor locus on the short arm of human chromosome 9 has been localized to a region of less than 40 kilobases by means of homozygous deletions in melanoma cell lines. This region contained a gene, Multiple Tumor Suppressor 1 (MTS1), that encodes a previously identified inhibitor (p16) of cyclin-dependent kinase 4. MTS1 was homozygously deleted at high frequency in cell lines derived from tumors of lung, breast, brain, bone, skin, bladder, kidney, ovary, and lymphocyte… CONTINUE READING
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