A cell cycle-dependent internal ribosome entry site.

  title={A cell cycle-dependent internal ribosome entry site.},
  author={St{\'e}phane Pyronnet and Lucien Pradayrol and Nahum Sonenberg},
  journal={Molecular cell},
  volume={5 4},
The eukaryotic mRNA 5' cap structure facilitates translation. However, cap-dependent translation is impaired at mitosis, suggesting a cap-independent mechanism for mRNAs translated during mitosis. Translation of ornithine decarboxylase (ODC), the rate-limiting enzyme in the biosynthesis of polyamines, peaks twice during the cell cycle, at the G1/S transition and at G2/M. Here, we describe a cap-independent internal ribosome entry site (IRES) in the ODC mRNA that functions exclusively at G2/M… CONTINUE READING
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