A cell culture model of the blood-brain barrier

@article{Rubin1991ACC,
  title={A cell culture model of the blood-brain barrier},
  author={Lee L Rubin and Deborah E. Hall and Sue Kingsbery interviewee. Porter and Katia Le Barbu and Celia Cannon and Heidi C. Horner and Mary J. Janatpour and Chen Wang Liaw and Kizzie Manning and Joshua Morales},
  journal={The Journal of Cell Biology},
  year={1991},
  volume={115},
  pages={1725 - 1735}
}
Endothelial cells that make up brain capillaries and constitute the blood-brain barrier become different from peripheral endothelial cells in response to inductive factors found in the nervous system. We have established a cell culture model of the blood-brain barrier by treating brain endothelial cells with a combination of astrocyte-conditioned medium and agents that elevate intracellular cAMP. These cells form high resistance tight junctions and exhibit low rates of paracellular leakage and… CONTINUE READING

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