A cell-based system for hepatitis B virus replication: significance of clinically enhanced viral replication in relation to deletions in viral core promoter.

@article{Hong2005ACS,
  title={A cell-based system for hepatitis B virus replication: significance of clinically enhanced viral replication in relation to deletions in viral core promoter.},
  author={Pan Hong and Lisa F P Ng and Ee Chee Ren and Wei Ning Chen},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2005},
  volume={10},
  pages={2001-4}
}
The core promoter of hepatitis B virus (HBV) is crucial in viral replication. Our previous investigation in clinical serum samples indicated that deletions in the viral core promoter (from nucleotide 1758 to 1777 and 1749 to 1768 respectively) may lead to increase in viral replication. We propose to characterize these deletion mutants in a cell-based system… CONTINUE READING