A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4.

@article{Topp2008ACS,
  title={A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4.},
  author={Justin D Topp and Jason K. Jackson and Alexis A Melton and Kristen W. Lynch},
  journal={RNA},
  year={2008},
  volume={14 10},
  pages={2038-49}
}
The human CD45 gene encodes a protein-tyrosine phosphatase that exhibits differential isoform expression in resting and activated T cells due to alternative splicing of three variable exons. Previously, we have used biochemical methods to identify two regulatory proteins, hnRNP L and PSF, which contribute to the activation-induced skipping of CD45 via the ESS1 regulatory element in variable exon 4. Here we report the identification of a third CD45 regulatory factor, hnRNP L-like (hnRNP LL), via… CONTINUE READING

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stability

  • L. H. Hung, M. Heiner, J. Hui, S. Schreiner, V. Benes, A. Bindereif
  • 2008
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