A cell-based model of thrombin generation.

  title={A cell-based model of thrombin generation.},
  author={Harold R. Roberts and M. Hoffman and Dougald M Monroe},
  journal={Seminars in thrombosis and hemostasis},
  volume={32 Suppl 1},
We have developed a cell-based model of thrombin generation using activated monocytes as a source of tissue factor (TF) and platelets serving as a surface for thrombin generation. Monocytes are activated by lipopolysaccharide and express cell-bound TF. To these are added physiologic (plasma) concentrations of all the plasma procoagulants as well as TF pathway inhibitor, antithrombin, and C1-esterase inhibitor. Coagulation takes place in microtiter wells and is initiated by factor VIIa (FVIIa… CONTINUE READING

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