A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution.

Abstract

Mice lacking the chemokine stromal cell-derived factor/pre-B cell growth stimulating factor or its primary physiological receptor CXCR4 revealed defects in B lymphopoiesis and bone marrow myelopoiesis during embryogenesis. We show here that adoptive transfer experiments reveal a deficiency in long-term lymphoid and myeloid repopulation in adult bone marrow… (More)

Topics

5 Figures and Tables

Cite this paper

@article{Kawabata1999ACR, title={A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution.}, author={Kazuya Kawabata and Masanori Ujikawa and Tomohiro Egawa and Hirofumi Kawamoto and K. Tachibana and Hisashi Iizasa and Yoshihisa Katsura and T. Kishimoto and Takahiro Nagasawa}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1999}, volume={96 10}, pages={5663-7} }