A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein.

@article{Hayhurst2012ACD,
  title={A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein.},
  author={Monica Hayhurst and Amanda Kloster Wagner and Massimiliano Cerletti and Amy J Wagers and Lee L Rubin},
  journal={Developmental biology},
  year={2012},
  volume={368 2},
  pages={
          323-34
        }
}
Mutations in the Survival of Motor Neuron (SMN) gene underlie the development of spinal muscular atrophy (SMA), which currently represents the leading genetic cause of mortality in infants and toddlers. SMA is characterized by degeneration of spinal cord motor neurons and muscle atrophy. Although SMA is often considered to be a motor neuron disease, accumulating evidence suggests that muscle cells themselves may be affected by low levels of SMN. Here, we examine satellite cells, tissue-resident… CONTINUE READING
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