A cautionary note on the evaluation of biomarkers of subtypes of a single disease.

@article{Adewale2008ACN,
  title={A cautionary note on the evaluation of biomarkers of subtypes of a single disease.},
  author={Adeniyi J Adewale and Qi Feng Liu and Irina Dinu and Paul D Lampe and Bree L Mitchell and Yutaka Yasui},
  journal={American journal of epidemiology},
  year={2008},
  volume={168 6},
  pages={559-62}
}
Heterogeneity in the molecular characteristics of a disease presents a challenge to investigators attempting to identify biomarkers of the disease. Preceding the biomarker discovery effort with stratification within a heterogeneous disease group, which amounts to grouping disease cases into more homogeneous subtypes, seems to be a natural strategy for discovering subtype-specific biomarkers. This is because biologically more homogeneous subgroups are presumably easier to distinguish from the… CONTINUE READING

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